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Konishi Lab

Publications

Publications Funding

Publications

2026

  1. "A Gly-to-Ala Substitution Confers Choline Phosphotransferase Activity on the CDP-Ethanolamine-Specific Mammalian EPT1." Yasuhiro Horibata, Shoji Maeda, Akimitsu Konishi. Genes Cells 31(2) : e70095 (2026) DOI PubMed

2025

  1. "Breaking the pH Code: Acidification Triggers SASP and Inflammation in Cellular Senescence." Akimitsu Konishi. J Biochem. : mvaf080 (2025) DOI PubMed
  2. "Dysregulated metabolic pathways of pulmonary fibrosis and the lipids associated with the effects of nintedanib therapy." Yasuo Shimizu, Yasuhiro Horibata, Mariko Domae, Yusuke Nakamura, Tatsuya Yokoyama, Ryo Arai, Taichi Shiobara, Akihiro Takemasa, Ryosuke Koike, Nobuhiko Uchida, Meitetsu Masawa, Rinna Tei, Taiji Watanabe, Hiroko Morita, Masaaki Miyoshi, Sayo Soda, Seiji Niho, Ko Igami, Hiroyuki Sugimoto. Respir Res. 26(1) : 166 (2025) DOI PubMed
  3. "Targeting Autophagy for Pituitary Tumors." Evan Yin, Motoyasu Satou, Toru Tateno. Cancers (Basel) 17(9) : 1402 (2025) DOI PubMed
  4. "Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase." Jacquelyn R Roberts, Yasuhiro Horibata, Frank E Kwarcinski, Vinson Lam, Ashleigh M Raczkowski, Akane Hubbard, Betsy White, Hiroyuki Sugimoto, Gregory G Tall, Melanie D Ohi, Shoji Maeda. Nat Commun. 16(1) : 111 (2025) DOI PubMed

2024

  1. "Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice." Masahiko Itoh, Kenji Watanabe, Yoichi Mizukami, Hiroyuki Sugimoto. Cell Struct Funct. 49(2) : 83-99 (2024) DOI PubMed
  2. "Branched-chain amino acid metabolism is a crucial modulator of cellular senescence." Yuma Aramaki, Kazuki Irie, Hideru Obinata, Shinya Honda, Takuro Horii, Satoko Arakawa, Aiko Tsuchida, Junki Hoshino, Ryosuke Kobayashi, Takashi Izumi, Izuho Hatada, Shigeomi Shimizu, Yoji A. Minamishima, Akimitsu Konishi. bioRxiv (2024) DOI
  3. "Structural reconstruction of mouse acute aortic dissection by intravenously administered human Muse cells without immunosuppression." Makoto Takahashi, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Yasuhiro Horibata, Hiroyuki Sugimoto, Mari Dezawa, Yoshikatsu Saiki. Commun Med (Lond). 4(1) : 174 (2024) DOI PubMed
  4. "Hamster spermatozoa incorporate hypotaurine via TauT for self-protection." Gen L Takei, Yasuhiro Horibata, Fubito Toyama, Keitaro Hayashi, Asuka Morita, Motoshi Ouchi, Tomoe Fujita. Reproduction 168(2) : e240022 (2024) DOI PubMed
  5. "Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors." Motoyasu Satou, Jason Wang, Tae Nakano-Tateno, Mariko Teramachi, Shigeki Aoki, Hiroyuki Sugimoto, Constance Chik, Toru Tateno. Mol Cell Endocrinol. 586 : 112196 (2024) DOI PubMed
  6. "The ceramide transport protein CERT is involved in alkylacylglycerol transfer from the ER to the Golgi for the biosynthesis of ether phospholipid." Yasuhiro Horibata, Hiroyuki Sugimoto. Arch Biochem Biophys. : 109871 (2024) DOI PubMed

2023

  1. "Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3." Keisuke Kiyozuka, Xian Zhao, Akimitsu Konishi, Yoji Andrew Minamishima, Hideru Obinata. J Biochem. 174(3) : 253-266 (2023) DOI PubMed
  2. "Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1." Xian Zhao, Keisuke Kiyozuka, Akimitsu Konishi, Reika Kawabata-Iwakawa, Yoji Andrew Minamishima, Hideru Obinata. J Biol Chem. 299(7) : 104851 (2023) DOI PubMed

2022

  1. "Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells." Hiroaki Shimizu, Yasuhiro Horibata, Izuki Amano, Megan J Ritter, Mariko Domae, Hiromi Ando, Hiroyuki Sugimoto, Ronald N Cohen, Anthony N Hollenberg. PLoS One 17(12) : e0277830 (2022) DOI PubMed
  2. "Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS." Yasutake Shinohara, Hiromi Ando, Masamitsu Maekawa, Maki Arai, Yasuhiro Horibata, Motoyasu Satou, Teruo Jojima, Isao Usui, Yoshimasa Aso, Hiroyuki Sugimoto. Biochim Biophys Acta Mol Cell Biol Lipids. 1867(6) : 159136 (2022) DOI PubMed
  3. "Metabolic changes induced by TGF-β1 via reduced expression of phosphatidylserine decarboxylase during myofibroblast transition." Nobuhiko Uchida, Yasuo Shimizu, Mio Fujimaki, Yasuhiro Horibata, Yusuke Nakamura, Yukiko Horigane, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Seiji Niho. Clin Biochem Nutr. 70(2) : 108-116 (2022) DOI PubMed

2021

  1. "Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas." Cyndy Liu, Tae Nakano-Tateno, Motoyasu Satou, Constance Chik, Toru Tateno. Endocr J. 68(10) : 1143-1153 (2021) DOI PubMed
  2. "Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids." Yasuhiro Horibata, Hiroyuki Sugimoto. J Lipid Res. 62 : 100100 (2021) DOI PubMed
  3. "Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export." Takahiro Nagatake, Yan-Chun Zhao, Takeshi Ito, Masahiko Itoh, Kohei Kometani, Mikio Furuse, Azusa Saika, Eri Node, Jun Kunisawa, Nagahiro Minato, Yoko Hamazaki. Int Immunol. 33(3) : 171-182 (2021) DOI PubMed
  4. "The zonula occludens protein family regulates the hepatic barrier system in the murine liver." Masahiko Itoh, Misao Terada, Hiroyuki Sugimoto. Biochim Biophys Acta Mol Basis Dis. 1867(1) : 165994 (2021) DOI PubMed

2020

  1. "Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels." Shawn M Lamothe, Nazlee Sharmin, Grace Silver, Motoyasu Satou, Yubin Hao, Toru Tateno, Victoria A Baronas, Harley T Kurata. Elife 9 : e54916 (2020) DOI PubMed
  2. "Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription." Yuji Tanaka, Hideru Obinata, Akimitsu Konishi, Noriyuki Yamagiwa, Makoto Tsuneoka. Cells 9(10) : 2266 (2020) DOI PubMed
  3. "L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells." Motoyasu Satou, Jason Wang, Tae Nakano-Tateno, Mariko Teramachi, Tokiko Suzuki, Keitaro Hayashi, Shawn Lamothe, Yubin Hao, Harley Kurata, Hiroyuki Sugimoto, Constance Chik, Toru Tateno. Mol Cell Endocrinol. 515 : 110868 (2020) DOI PubMed
  4. "Effects of CAPTEM (Capecitabine and Temozolomide) on a Corticotroph Carcinoma and an Aggressive Corticotroph Tumor." Tae Nakano-Tateno, Motoyasu Satou, Naoko Inoshita, Frank K H van Landeghem, Jay Easaw, Vivek Mehta, Toru Tateno, Constance L Chik. Endocr Pathol. 32(3) : 418-426 (2020) DOI PubMed
  5. "Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids." Yasuhiro Horibata, Hiromi Ando, Hiroyuki Sugimoto. J Lipid Res. 61(8) : 1221-1231 (2020) DOI PubMed
  6. "Imaging of lysophosphatidylcholine in an induced pluripotent stem cell-derived endothelial cell network." Yasuo Shimizu, Yusuke Nakamura, Yasuhiro Horibata, Mio Fujimaki, Keitaro Hayashi, Nobuhiko Uchida, Hiroko Morita, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto. Regen Ther. 14 : 299-305 (2020) DOI PubMed
  7. "Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice." Zi Wang, Toshimitsu Komatsu, Yoshihisa Ohata, Yukari Watanabe, Yiwen Yuan, Yuki Yoshii, Seongjoon Park, Ryoichi Mori, Motoyasu Satou, Yoshitaka Kondo, Isao Shimokawa, Takuya Chiba. Geriatr Gerontol Int. 20(3) : 238-247 (2020) DOI PubMed
  8. "The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts." Yasuhiro Horibata, Satomi Mitsuhashi, Hiroaki Shimizu, Sho Maejima, Hirotaka Sakamoto, Chieko Aoyama, Hiromi Ando, Hiroyuki Sugimoto. Sci Rep. 10(1) : 2845 (2020) DOI PubMed

2019

  1. "Characterization of glycerophosphodiesterase 4-interacting molecules Gαq/11 and Gβ, which mediate cellular lysophospholipase D activity." Chieko Aoyama, Yasuhiro Horibata, Hiromi Ando, Satomi Mitsuhashi, Maki Arai, Hiroyuki Sugimoto. Biochem J. 476(24) : 3721-3736 (2019) DOI PubMed
  2. "Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level." Yuji Tanaka, Akimitsu Konishi, Hideru Obinata, Makoto Tsuneoka. Sci Rep. 9(1) : 18694 (2019) DOI PubMed
  3. "Side-chain oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation." Hiromi Ando, Yasuhiro Horibata, Chieko Aoyama, Hiroaki Shimizu, Yasutake Shinohara, Satoko Yamashita, Hiroyuki Sugimoto. J Steroid Biochem Mol Biol. 195 : 105482 (2019) DOI PubMed
  4. "Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet." Sereana Wan, Folkert Kuipers, Rick Havinga, Hiromi Ando, Dennis E Vance, René L Jacobs, Jelske N van der Veen. Hepatol Commun. 3(2) : 262-276 (2019) DOI PubMed

2018

  1. "Effects of the differential expression of ZO-1 and ZO-2 on podocyte structure and function." Masahiko Itoh, Kazuhiko Nakadate, Taiji Matsusaka, Walter Hunziker, Hiroyuki Sugimoto. Genes Cells 23(7) : 546-556 (2018) DOI PubMed
  2. "EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans." Yasuhiro Horibata, Orly Elpeleg, Ayelet Eran, Yoshio Hirabayashi, David Savitzki, Galit Tal, Hanna Mandel, Hiroyuki Sugimoto. Genes Cells 59(6) : 1015-1026 (2018) DOI PubMed
  3. "Dram1 regulates DNA damage-induced alternative autophagy." Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Cell Stress 2(3) : 55-65 (2018) DOI PubMed

2017

  1. "The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells." Masahiko Itoh, Derek C Radisky, Masaaki Hashiguchi, Hiroyuki Sugimoto. Oncotarget 8(54) : 92157-92170 (2017) DOI PubMed
  2. "Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer." Yasuhiro Horibata, Hiromi Ando, Motoyasu Satou, Hiroaki Shimizu, Satomi Mitsuhashi, Yasuo Shimizu, Masahiko Itoh, Hiroyuki Sugimoto. Sci Rep. 7(1) : 8793 (2017) DOI PubMed
  3. "Changes of plasmalogen phospholipid levels during differentiation of induced pluripotent stem cells 409B2 to endothelial phenotype cells." Yusuke Nakamura, Yasuo Shimizu, Yasuhiro Horibata, Rinna Tei, Ryosuke Koike, Meitetsu Masawa, Taiji Watanabe, Taichi Shiobara, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Yoshiki Ishii. Sci Rep. 7(1) : 9377 (2017) DOI PubMed
  4. "Matrix-assisted laser desorption/ionization imaging mass spectrometry reveals changes of phospholipid distribution in induced pluripotent stem cell colony differentiation." Yasuo Shimizu, Motoyasu Satou, Keitaro Hayashi, Yusuke Nakamura, Mio Fujimaki, Yasuhiro Horibata, Hiromi Ando, Taiji Watanabe, Taichi Shiobara, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Naohiko Anzai, Yoshiki Ishii. Anal Bioanal Chem. 409(4) : 1007-1016 (2017) DOI PubMed

2016

  1. "Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis." Yutaka Mizuki, Manabu Takaki, Shinji Sakamoto, Sojiro Okamoto, Makiko Kishimoto, Yuko Okahisa, Masahiko Itoh, Norihito Yamada. Int J Mol Sci. 18(1) : 67 (2016) DOI PubMed
  2. "StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria." Yasuhiro Horibata, Hiromi Ando, Peixiang Zhang, Laurent Vergnes, Chieko Aoyama, Masahiko Itoh, Karen Reue, Hiroyuki Sugimoto. J Biol Chem. 291(48) : 24880-24891 (2016) DOI PubMed
  3. "Autophagy controls centrosome number by degrading Cep63." Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu. Nat Commun. 7 : 13508 (2016) DOI PubMed
  4. "Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase." Mari Araki, Noriyasu Ohshima, Chizu Aso, Akimitsu Konishi, Hideru Obinata, Kazuaki Tatei, Takashi Izumi. J Biochem. 160(5) : 269-279 (2016) DOI PubMed
  5. "TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends." Akimitsu Konishi, Takashi Izumi, Shigeomi Shimizu. J Biol Chem. 291(39) : 20798-810 (2016) DOI PubMed
  6. "Mole ghrelin: cDNA cloning, gene expression, and diverse molecular forms in Mogera imaizumii." Motoyasu Satou, Hiroyuki Kaiya, Yoshihiro Nishi, Akio Shinohara, Shin-Ichiro Kawada, Mikiya Miyazato, Kenji Kangawa, Hiroyuki Sugimoto. Gen Comp Endocrinol. 232 : 199-210 (2016) DOI PubMed
  7. "Protein purification and cloning of diacylglycerol lipase from rat brain." Chizu Aso, Mari Araki, Noriyasu Ohshima, Kazuaki Tatei, Tohko Hirano, Hideru Obinata, Mikiko Kishi, Koji Kishimoto, Akimitsu Konishi, Fumio Goto, Hiroyuki Sugimoto, Takashi Izumi. J Biochem. 159(6) : 585-97 (2016) DOI PubMed

2015

  1. "Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1." Hiromi Ando, Chieko Aoyama, Yasuhiro Horibata, Motoyasu Satou, Satomi Mitsuhashi, Masahiko Itoh, Kohei Hosaka, Hiroyuki Sugimoto. Biochem J. 471(3) : 369-79 (2015) DOI PubMed
  2. "Identification of activated protein C as a ghrelin endopeptidase in bovine plasma." Motoyasu Satou, Yoshihiro Nishi, Akira Hishinuma, Hiroshi Hosoda, Kenji Kangawa, Hiroyuki Sugimoto. J Endocrinol. 224(1) : 61-73 (2015) DOI PubMed

2014

  1. "Three distinct subsets of thymic epithelial cells in rats and mice defined by novel antibodies." Yasushi Sawanobori, Hiashi Ueta, Christine D Dijkstra, Chae Gyu Park, Motoyasu Satou, Yusuke Kitazawa, Kenjiro Matsuno. PLoS One 9(10) : e109995 (2014) DOI PubMed
  2. "The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1." Masahiko Itoh, Kazuhiko Nakadate, Yasuhiro Horibata, Taiji Matsusaka, Jianliang Xu, Walter Hunziker, Hiroyuki Sugimoto. PLoS One. 9(9) : e106621 (2014) DOI PubMed

2013

  1. "Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12." Yasuhiro Horibata`, Hiromi Ando, Masahiko Itoh, Hiroyuki Sugimoto. J Lipid Res." 54(8) : 2049-2059 (2013) DOI PubMed
  2. "ARHGEF11, a regulator of junction-associated actomyosin in epithelial cells." Masahiko Itoh. Tissue Barriers 1(2) : e24221 (2013) DOI PubMed

2012

  1. "Transmembrane topology and oligomeric structure of the high-affinity choline transporter." Takashi Okuda, Chieko Osawa, Haruhiko Yamada, Kengo Hayashi, Shizue Nishikawa, Tomoko Ushio, Yuji Kubo, Motoyasu Satou, Haruo Ogawa, Tatsuya Haga. J Biol Chem. 287(51) : 42826-34 (2012) DOI PubMed
  2. "Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling." Masahiko Itoh, Sachiko Tsukita, Yuji Yamazaki, Hiroyuki Sugimoto. Proc Natl Acad Sci U S A. 109(25) : 9905-10 (2012) DOI PubMed
  3. "Involvement of Beclin 1 in engulfment of apoptotic cells." Akimitsu Konishi, Satoko Arakawa, Zhenyu Yue, Shigeomi Shimizu. J Biol Chem. 287(17) : 13919-29 (2012) DOI PubMed

2011

  1. "The heterotrimeric G protein subunits Gα(q) and Gβ(1) have lysophospholipase D activity." Chieko Aoyama, Hiroyuki Sugimoto, Hiromi Ando, Satoko Yamashita, Yasuhiro Horibata, Sayaka Sugimoto, Motoyasu Satou. Biochem J. 440(2) : 241-50 (2011) DOI PubMed

2010

  1. "Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium." Motoyasu Satou, Yoshihiro Nishi, Junko Yoh, Yoshiyuki Hattori, Hiroyuki Sugimoto. Endocrinology 151(10) : 4765-75 (2010) DOI PubMed
  2. "Involvement of JNK in the regulation of autophagic cell death." Shigeomi Shimizu, Akimitsu Konishi, Yuya Nishida, Takeshi Mizuta, Hiroshi Nishina, Akitsugu Yamamoto, Yoshihide Tsujimoto. Oncogene 29(14) : 2070-82 (2010) DOI PubMed
  3. "Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro." Hiromi Ando, Yasuhiro Horibata, Satoko Yamashita, Tetsunari Oyama, Hiroyuki Sugimoto. Biochim Biophys Acta. 1801(4) : 487-95 (2010) DOI PubMed
  4. "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria." Yasuhiro Horibata, Hiroyuki Sugimoto. J Biol Chem. 285(10) : 7358-65 (2010) DOI PubMed

2009

  1. "A novel fucosyl glycosphingolipid of brine shrimp that is highly sensitive to endoglycoceramidase." Xu Xu, Yasuhiro Horibata, Masanori Inagaki, Yoichiro Hama, Keishi Sakaguchi, Hatsumi M Goda, Nozomu Okino, Makoto Ito. Glycobiology 19(12) : 1446-51 (2009) DOI PubMed
  2. "Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents." Hiroshi Hiejima, Yoshihiro Nishi, Hiroshi Hosoda, Junko Yoh, Hiroharu Mifune, Motoyasu Satou, Hiroyuki Sugimoto, Seiichi Chiba, Yukie Kawahara, Eiichiro Tanaka, Hironobu Yoshimatsu, Naohisa Uchimura, Kenji Kangawa, Masayasu Kojima. Regul Pept. 156(1-3) : 47-56 (2009) DOI PubMed
  3. "Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins." Makoto Adachi, Yoko Hamazaki, Yuka Kobayashi, Masahiko Itoh, Sachiko Tsukita, Mikio Furuse, Shoichiro Tsukita. Mol Cell Biol. 29(9) : 2372-89 (2009) DOI PubMed
  4. "Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells." Koichi Okamura, Satoko Yamashita, Hiromi Ando, Yasuhiro Horibata, Chieko Aoyama, Kenji Takagishi, Takashi Izumi, Dennis E Vance, Hiroyuki Sugimoto. Biochim Biophys Acta. 1791(3) : 173-82 (2009) DOI PubMed

2008

  1. "Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells." Tatsuya Katsuno, Kazuaki Umeda, Takeshi Matsui, Masaki Hata, Atsushi Tamura, Masahiko Itoh, Kosei Takeuchi, Toshihiko Fujimori, Yo-ichi Nabeshima, Tetsuo Noda, Shoichiro Tsukita, Sachiko Tsukita. Mol Biol Cell. 19(6) : 2465-75 (2008) DOI PubMed
  2. "Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2." Akimitsu Konishi, Titia de Lange. Genes Dev. 22(9) : 1221-30 (2008) DOI PubMed

2007

  1. "Fucoganglioside alpha-fucosyl(alpha-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis." Yasuhiro Yamazaki, Yasuhiro Horibata, Yasuko Nagatsuka, Yoshio Hirabayashi, Tsutomu Hashikawa. Biochem J. 407(1) : 31-40 (2007) DOI PubMed
  2. "Sensitivity of phosphatidylglucoside against phospholipases." Yasuhiro Horibata, Yasuko Nagatsuka, Peter Greimel, Yukishige Ito, Yoshio Hirabayashi. Anal Biochem. 365(1) : 149-51 (2007) DOI
  3. "Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells." Masahiko Itoh, Celeste M Nelson, Connie A Myers, Mina J Bissell. Cancer Res. 67(10) : 4759-66 (2007) DOI PubMed
  4. "A novel endoglycoceramidase hydrolyzes oligogalactosylceramides to produce galactooligosaccharides and ceramides." Yohei Ishibashi, Toru Nakasone, Masashi Kiyohara, Yasuhiro Horibata, Keishi Sakaguchi, Atsushi Hijikata, Sachiyo Ichinose, Akira Omori, Yasuyuki Yasui, Akihiro Imamura, Hideharu Ishida, Makoto Kiso, Nozomu Okino, Makoto Ito. J Biol Chem. 282(15) : 11386-96 (2007) DOI PubMed
  5. "Identification and characterization of human ethanolaminephosphotransferase1." Yasuhiro Horibata, Yoshio Hirabayashi. J Lipid Res. 48(3) : 503-8 (2007) DOI PubMed
  6. "Expression of a functional sphingomyelinase of Pseudomonas sp. TK4 in mammalian cells." Yasuhiro Horibata, Noriyuki Sueyoshi, Makoto Ito. Biosci Biotechnol Biochem. 71(2) : 603-6 (2007) DOI PubMed

2006

  1. "Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein." Makoto Adachi, Akihito Inoko, Masaki Hata, Kyoko Furuse, Kazuaki Umeda, Masahiko Itoh, Shoichiro Tsukita. Mol Cell Biol. 26(23) : 9003-15 (2006) DOI
  2. "Phosphatidylglucoside exists as a single molecular species with saturated fatty acyl chains in developing astroglial membranes." Yasuko Nagatsuka, Yasuhiro Horibata, Yasuhiro Yamazaki, Masami Kinoshita, Yoko Shinoda, Tsutomu Hashikawa, Hiroyuki Koshino, Takemichi Nakamura, Yoshio Hirabayashi. Biochemistry 45(29) : 8742-50 (2006) DOI PubMed

2005

  1. "Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha." Hiroyuki Sugimoto, Koichi Okamura, Sayaka Sugimoto, Motoyasu Satou, Tomoyasu Hattori, Dennis E Vance, Takashi Izumi. J Biol Chem. 280(49) : 40857-66 (2005) DOI PubMed
  2. "Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay." Katsuhiko Endo, Akimitsu Konishi, Hidefumi Sasaki, Minoru Takada, Hisaichi Tanaka, Meinoshin Okumura, Masaaki Kawahara, Hironori Sugiura, Yoshiyuki Kuwabara, Ichiro Fukai, Akihide Matsumura, Motoki Yano, Yoshihiro Kobayashi, Kotaro Mizuno, Hiroshi Haneda, Eriko Suzuki, Keiji Iuchi, Yoshitaka Fujii. Lung Cancer 50(3) : 375-84 (2005) DOI PubMed
  3. "Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe." Hiroyuki Niida, Shinji Tsuge, Yuko Katsuno, Akimitsu Konishi, Naoki Takeda, Makoto Nakanishi. J Biol Chem. 280(47) : 39246-52 (2005) DOI PubMed
  4. "A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates." Yasuhiro Hayashi, Yasuhiro Horibata, Keishi Sakaguchi, Nozomu Okino, Makoto Ito. Anal Biochem. 345(2) : 181-6 (2005) DOI PubMed
  5. "The glycosphingolipid receptor for Vibrio trachuri in the red sea bream intestine is a GM4 ganglioside which contains 2-hydroxy fatty acids." Shin-ichi Chisada, Yasuhiro Horibata, Yoichiro Hama, Masanori Inagaki, Naruto Furuya, Nozomu Okino, Makoto Ito. Biochem Biophys Res Commun. 333(2) : 367-73 (2005) DOI PubMed
  6. "EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler." Hidefumi Sasaki, Katsuhiko Endo, Akimitsu Konishi, Minoru Takada, Masaaki Kawahara, Keiji Iuchi, Akihide Matsumura, Meinoshin Okumura, Hisaichi Tanaka, Tomoya Kawaguchi, Toshiki Shimizu, Hiroshi Takeuchi, Motoki Yano, Ichiro Fukai, Yoshitaka Fujii. Clin Cancer Res. 11(8) : 2924-9 (2005) DOI PubMed

2004

  1. "Unique catabolic pathway of glycosphingolipids in a hydrozoan, Hydra magnipapillata, involving endoglycoceramidase." Yasuhiro Horibata, Keishi Sakaguchi, Nozomu Okino, Hiroshi Iida, Masanori Inagaki, Toshitaka Fujisawa, Yoichiro Hama, Makoto Ito. J Biol Chem. 279(32) : 33379-89 (2004) DOI PubMed
  2. "Elevated serum epidermal growth factor receptor level in stage IV thymoma." Hidefumi Sasaki, Haruhiro Yukiue, Atsushi Sekimura, Kotaro Mizuno, Akimitsu Konishi, Motoki Yano, Ichiro Fukai, Yoshitaka Fujii. Surg Today 34(5) : 477-9 (2004) DOI PubMed
  3. "Endostatin gene transfection using a cationic lipid: advantages of transfection before tumor cell inoculation and repeated transfection." Motoki Yano, Yoshiaki Nakashima, Yoshihiro Kobayashi, Kotaro Mizuno, Akimitsu Konishi, Hidefumi Sasaki, Ichiro Fukai, Ronald K Scheule, Yoshitaka Fujii. Cancer Gene Ther. 11(5) : 354-62 (2004) DOI PubMed
  4. "Expression of Smac/DIABLO is a novel prognostic marker in lung cancer." Atsushi Sekimura, Akimitsu Konishi, Kotaro Mizuno, Yoshihiro Kobayashi, Hidefumi Sasaki, Motoki Yano, Ichiro Fukai, Yoshitaka Fujii. Oncol Rep. 11(4) : 797-802 (2004) DOI PubMed

2003

  1. "Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues." Akihito Inoko, Masahiko Itoh, Atsushi Tamura, Miho Matsuda, Mikio Furuse, Shoichiro Tsukita. Genes Cells 8(11) : 837-45 (2003) DOI PubMed
  2. "The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis." Masahiko Itoh, Mina J Bissell. J Mammary Gland Biol Neoplasia. 8(4) : 449-62 (2003) DOI PubMed
  3. "Angioarrestin mRNA expression in early-stage lung cancers." Hidefumi Sasaki, Satoru Moriyama, Atsushi Sekimura, Kotaro Mizuno, Haruhiro Yukiue, Akimitsu Konishi, Motoki Yano, Masahiro Kaji, Ichiro Fukai, Yosuke Yamakawa, Yoshitaka Fujii. Eur J Surg Oncol. 29(8) : 649-53 (2003) DOI PubMed
  4. "Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks." Akimitsu Konishi, Shigeomi Shimizu, Junko Hirota, Toshifumi Takao, Yuhong Fan, Yosuke Matsuoka, Lilin Zhang, Yoshihiro Yoneda, Yoshitaka Fujii, Arthur I Skoultchi, Yoshihide Tsujimoto. Cell 114(6) : 673-88 (2003) DOI PubMed
  5. "Cten mRNA expression was correlated with tumor progression in lung cancers." Hidefumi Sasaki, Satoru Moriyama, Kotaro Mizuno, Haruhiro Yukiue, Akimitsu Konishi, Motoki Yano, Masahiro Kaji, Ichiro Fukai, Masanobu Kiriyama, Yosuke Yamakawa, Yoshitaka Fujii. Lung Cancer 40(2) : 151-5 (2003) DOI PubMed
  6. "Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer." Hidefumi Sasaki 1, Haruhiro Yukiue, Kotaro Mizuno, Atsushi Sekimura, Akimitsu Konishi, Motoki Yano, Masahiro Kaji, Masanobu Kiriyama, Ichiro Fukai, Yosuke Yamakawa, Yoshitaka Fujii. Int J Clin Oncol. 8(2) : 79-82 (2003) DOI PubMed

2002

  1. "Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis." Kazumasa Morita, Mikio Furuse, Yoko Yoshida, Masahiko Itoh, Hiroyuki Sasaki, Shoichiro Tsukita, Yoshiki Miyachi. J Invest Dermatol. 118(6) : 1073-9 (2002) DOI PubMed
  2. "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule." Yoko Hamazaki, Masahiko Itoh, Hiroyuki Sasaki, Mikio Furuse, Shoichiro Tsukita. J Biol Chem. 277(1) : 455-61 (2002) DOI PubMed

2001

  1. "Junctional adhesion molecule (JAM) binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions." Masahiko Itoh, Hiroyuki Sasaki, Mikio Furuse, Harunobu Ozaki, Toru Kita, Shoichiro Tsukita. J Cell Biol. 154(3) : 491-7 (2001) DOI PubMed
  2. "Transglycosylation and reverse hydrolysis reactions of endoglycoceramidase from the jellyfish, Cyanea nozakii." Yasuhiro Horibata, Hideyosbi Higashi, Makoto Ito. J Biochem. 130(2) : 263-8 (2001) DOI PubMed
  3. "Multifunctional strands in tight junctions." Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh. Nat Rev Mol Cell Biol. 2(4) : 285-93 (2001) DOI PubMed

2000

  1. "Purification, Characterization, and cDNA Cloning of a Novel Acidic Endoglycoceramidase from the Jellyfish, Cyanea nozakii." Yasuhiro Horibata, Nozomu Okino, Sachiyo Ichinose, Akira Omori, Makoto Ito. J Biol Chem. 275(40) : 31297-304 (2000) DOI PubMed
  2. "Lordosis-inhibiting effect of progesterone in male and female rats with septal lesions." Motoyasu Satou, Korehito Yamanouchi. Brain Res Bull. 53(3) : 331-4 (2000) DOI PubMed
  3. "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death." Shigeomi Shimizu, Akimitsu Konishi, Takashi Kodama, Yoshihide Tsujimoto. Proc Natl Acad Sci U S A. 97(7) : 3100-5 (2000) DOI PubMed

1999

  1. "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins." Masahiko Itoh, Mikio Furuse, Kazumasa Morita, Koji Kubota, Mitinori Saitou, Shoichiro Tsukita. J Cell Biol. 147(6) : 1351-63 (1999) DOI PubMed
  2. "Structural and signalling molecules come together at tight junctions." Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh. Curr Opin Cell Biol. 11(5) : 628-33 (1999) DOI PubMed
  3. "Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity." Yuhko Ando-Akatsuka, Shigenobu Yonemura, Masahiko Itoh, Mikio Furuse, Shoichiro Tsukita. J Cell Physiol. 179(2) : 115-25 (1999) DOI PubMed
  4. "Effect of direct application of estrogen aimed at lateral septum or dorsal raphe nucleus on lordosis behavior: regional and sexual differences in rats." Motoyasu Satou, Korehito Yamanouchi. Neuroendocrinology 69(6) : 446-52 (1999) DOI PubMed
  5. "Inhibitory effect of progesterone on androgen-induced lordosis in ovariectomized rats." Motoyasu Satou, Korehito Yamaguchi. Endocr J. 45(2) : 235-9 (1999) DOI PubMed
  6. "Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion." Yuzo Imamura, Masahiko Itoh, Yoshito Maeno, Shoichiro Tsukita, Akira Nagafuchi. J Cell Biol. 144(6) : 1311-22 (1999) DOI PubMed
  7. "Masahiko Itoh, Kazumasa Morita, Shoichiro Tsukita." Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 274(9) : 5981-6 (1999) DOI PubMed
  8. "Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout." Yoshinori Doi, Masahiko Itoh, Shigenobu Yonemura, Satoru Ishihara, Hiroshi Takano, Tetsuo Noda, Shoichiro Tsukita, Sachiko Tsukita. J Biol Chem. 274(4) : 2315-21 (1999) DOI PubMed

1998

  1. "Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin." Kazumasa Morita, Masahiko Itoh, Mitinori Saitou, Yuhko Ando-Akatsuka, Mikio Furuse, Kozo Yoneda, Sadao Imamura, Kazushi Fujimoto, Shoichiro Tsukita. J Invest Dermatol. 110(6) : 862-6 (1998) DOI PubMed
  2. "Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions." Mitinori Saitou, Kazushi Fujimoto, Yoshinori Doi, Masahiko Itoh, Toyoshi Fujimoto, Mikio Furuse, Hiroshi Takano, Tetsuo Noda, Shoichiro Tsukita. J Cell Biol. 141(2) : 397-408 (1998) DOI PubMed

1997

  1. "Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction." Kenji Mandai, Hiroyuki Nakanishi, Ayako Satoh, Hiroshi Obaishi, Manabu Wada, Hideo Nishioka, Masahiko Itoh, Akira Mizoguchi, Takeo Aoki, Toyoshi Fujimoto, Yoichi Matsuda, Shoichiro Tsukita, Yoshimi Takai. J Cell Biol. 139(2) : 517-28 (1997) DOI PubMed
  2. "Occludin as a possible determinant of tight junction permeability in endothelial cells." Tetsuaki Hirase, James M. Staddon, Mitinori Saitou, Yuhko Ando-Akatsuka, Masahiko Itoh, Mikio Furuse, Kazushi Fujimoto, Shoichiro Tsukita, Lee L. Rubin". J Cell Sci. 110(14) : 1603-13 (1997) DOI PubMed
  3. "Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments." Masahiko Itoh, Akira Nagafuchi, Seiji Moroi, Shoichiro Tsukita. J Cell Biol. 138(1) : 181-92 (1997) DOI PubMed

1996

  1. "Lordosis-inhibiting effect of progesterone in female rats with lesions in septum, preoptic area, or dorsal raphe nucleus." Motoyasu Satou, Korehito Yamaguchi. Physiol Behav. 60(3) : 1027-31 (1996) DOI PubMed
  2. "Inhibitory effect of progesterone on sexual receptivity in female rats: a temporal relationship to estrogen administration." Motoyasu Satou, Korehito Yamaguchi. Zoolog Sci. 13(4) : 609-13 (1996) DOI PubMed
  3. "Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues." Y Ando-Akatsuka, M Saitou, T Hirase, M Kishi, A Sakakibara, Masahiko Itoh, S Yonemura, M Furuse, S Tsukita. J Cell Biol. 133(1) : 43-7 (1996) DOI PubMed

1994

  1. "Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions." M Furuse, Masahiko Itoh, T Hirase, A Nagafuchi, S Yonemura, S Tsukita, S Tsukita. J Cell Biol. 127(6) : 1617-26 (1994) DOI PubMed
  2. "Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides." H Kasahara, Masahiko Itoh, T Sugiyama, N Kido, H Hayashi, H Saito, S Tsukita, N Kato. J Clin Invest. 94(3) : 1026-36 (1994) DOI PubMed

1993

  1. "Occludin: a novel integral membrane protein localizing at tight junctions." M Furuse, T Hirase, Masahiko Itoh, A Nagafuchi, S Yonemura, S Tsukita, S Tsukita. J Cell Biol. 123(6) : 1777-88 (1993) DOI PubMed
  2. "Submembranous junctional plaque proteins include potential tumor suppressor molecules." S Tsukita, Masahiko Itoh, A Nagafuchi, S Yonemura, S Tsukita. J Cell Biol. 123(5) : 1049-53 (1993) DOI PubMed
  3. "The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy." Masahiko Itoh, A Nagafuchi, S Yonemura, T Kitani-Yasuda, S Tsukita, S Tsukita. J Cell Biol. 121(3) : 491-502 (1993) DOI PubMed

1991

  1. "A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites." Masahiko Itoh, S Yonemura, A Nagafuchi, S Tsukita, S Tsukita. J Cell Biol. 115(5) : 1449-62 (1991) DOI PubMed

Funding

  1. 「分岐鎖アミノ酸代謝による細胞・個体老化の分子メカニズムの解明」 日本学術振興会 科学研究費助成事業 基盤研究(B) （25K02451） 2025-04 - 2028-03 . 代表：小西 昭充
  2. 「加齢黄斑変性におけるテロメア依存的RPE機能障害の病態生理的意義の解明」 日本学術振興会 科学研究費助成事業 基盤研究(C) （26K12522） 2026-04 - 2029-03 . 分担：小西 昭充 （研究代表者：秋山 英雄）
  3. 「膵頭十二指腸切除検体・膵液腸液を用いた膵癌微生物叢と代謝異常の包括的解析」 日本学術振興会 科学研究費助成事業 基盤研究(C) （26K08553） 2026-04 - 2031-03 . 分担：小西 昭充 （研究代表者：松本 尊嗣）
  4. 「遺伝性肝内胆汁うっ滞症の発症と病態におけるTight Junction分子の役割の解析」 日本学術振興会 科学研究費助成事業 基盤研究(C) （23K06485） 2023-04 - 2027-03 . 代表：伊藤 雅彦
  5. 「ミトコンドリアにおける新規リン脂質輸送タンパク質の破綻とミオパチー発症機構の解明」 日本学術振興会 科学研究費助成事業 基盤研究(C) （24K10055） 2024-04 - 2027-03 . 代表：堀端 康博
  6. 「ヒポタウリンによる射精前精子の保護機構の解明～生殖補助医療への応用を見据えて」 日本学術振興会 科学研究費助成事業 基盤研究(C) （25K12598） 2025-04 - 2028-03 . 分担：堀端 康博 （研究代表者：竹井 元）
  7. 「成長ホルモンの分泌機構に依存した寿命の制御」 日本学術振興会 科学研究費助成事業 基盤研究(C) （26K11452） 2026-04 - 2030-03 . 代表：佐藤 元康
  8. 「膵癌における分岐鎖アミノ酸代謝リプログラミングの解明」 日本学術振興会 科学研究費助成事業 基盤研究(C) （26K10091） 2026-04 - 2029-03 . 代表：安戸 博美
  9. 「分岐鎖アミノ酸代謝を起点とした老化制御機構の解明及び加齢性疾患治療へのアプローチ」 日本学術振興会 科学研究費助成事業 若手研究 （25K18726） 2025-04 - 2027-03 . 代表：入江 和樹